Latest Posters

Diagnostic Significance of microRNA Tumor Biomarkers in Fine Needle Aspirates (FNA) of Pancreatic Cancer
Martina Doleshal 1, Anna E. Szafranska 1, Hayward S. Edmunds 2, Gregory J. Tsongalis 2, Murray Korc 2 and Emmanuel Labourier 1,
Asuragen, Inc., Dartmouth Medical School and Dartmouth Hitchcock Medical Center

Collection of pancreatic fine needle aspirates (FNAs) in RNARetain™ allows stabilization and protection of RNA in tissues containing high levels of nucleases; Differential miRNA expression in pancreatic FNAs accurately classifies benign and malignant tissue; Combinations of miRNA and mRNA expression signatures improve the separation between normal tissue and chronic pancreatitis; microRNAs are suitable analytes for molecular characterization of fine needle aspirates from pancreatic tissues.

Apoptosis Inducing Novel microRNA for Breast cancer and Hepatocellular Carcinoma
Arutselvan Natarajan, Sally J. DeNardo, Mark A. Zern, Senthil K. Venugopal, UC Davis Medical Center

MicroRNA provides a mechanism to target cancer stem cells and restraint tumors cells permanently; this could lead to promising cancer therapeutics and imaging agents. Apoptosis inducing microRNA was identified to target HCC and breast cancer cells for imaging and therapy.

A genome-wide loss of function screen identifies new genes required for lung cancer cell proliferation
PINNA G, ARAUJO N, MOROZOVA N, DETREZ MA & HAREL-BELLAN A,
CNRS

RNA interference (RNAi) provides an experimental tool for functional genomics analysis. We screened a genome-wide RNAi library to identify new genes involved in lung cancer cell proliferation. 72 % from the 257 genes identified were involved in general gene expression processes, 16 % were of unknown function or unrelated to proliferation, and 12% consisted of uncharacterized genes. These last sets of genes provide potential novel targets for lung cancer treatment.

Computational analysis of high-throughputsmall RNA sequencing reveals microRNAs in a single-celled organism
Schwach F, Studholme DJ, Molnar A, Thuenemann E, Burrell M, Perez-Martinez A, Moulton V and Baulcombe D,
University of East Anglia, Sainsbury Laboratory

We present evidence that miRNA precursors are present in the single-celled green alga Chlamydomonas reinhardtii and that they give rise to mature miRNAs that regulate target genes by post-transcriptional RNA cleavage.

Specific Ligand-Based Depletion of Human Albumin and IgG in the Presence of Denaturants
Todd Sanderson, Hongshan Li, Brian Miller, Laura Alionte, and Lisa Bradbury,
Pall Life Sciences

Poster data highlights the advantages of a ligand-based depletion method that functions in the presence of urea and is highly specific, disposable, cost effective, and flexible.

A New Disposable, Specific Ligand-Based Method for Depletion of Albumin and IgG From Serum and Plasma
Laura Alionte, Allison Miller, Cal Messing, Tao Hu, and Lisa Bradbury,
Pall Life Sciences

Poster shows the advantages of a ligand-based depletion method that is highly specific, disposable, cost effective, and flexible. Pall’s Enchant Multi-Protein Affinity Separation Kit is a strong addition to the product choices for scientists engaged in biomarker discovery and proteomics research.