Witold Filipowicz - Novartis Research Foundation

We are studying biology and biochemistry of RNAi, and biogenesis and function of microRNAs in cultured mammalian cells and during mouse development. We characterize factors involved in RNAi, with a focus on Dicer (an RNase III-like 220-kD nuclease triggering RNAi, and also essential for biogenesis of all microRNAs) and its protein partners. Moreover, we are interested in a role of RNAi machinery in chromatin modification and remodeling. An involvement of components of RNAi in chromatin transactions has been shown for lower eukaryotes and plants, but not so far for mammals.

Further Information: http://www.fmi.ch/default.asp?item_id=287